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Taurine supplement in early life altered islet morphology, decreased insulitis and delayed the onset of diabetes in non-obese diabetic mice

机译:在非肥胖型糖尿病小鼠中,牛磺酸补充剂可改善胰岛的形态,降低其胰岛炎并延缓糖尿病的发作

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摘要

We hypothesised that nutritional taurine, which is important for the development of the endocrine pancreas and reduces cytokine-induced apoptosis in pancreatic beta cells, would prevent or delay the onset of autoimmune diabetes, if given early in life to the non-obese diabetic (NOD) mouse.
机译:我们假设营养牛磺酸,如果在生命早期给予非肥胖型糖尿病(NOD),它对预防内分泌胰腺的生长和减少胰腺β细胞中细胞因子诱导的细胞凋亡很重要,它将预防或延迟自身免疫性糖尿病的发作。 ) 老鼠。

著录项

  • 来源
    《Diabetologia》 |2004年第10期|1831-1837|共7页
  • 作者单位

    Lawson Health Research Institute St. Joseph’s Health CareDepartment of Medicine University of Western Ontario;

    Lawson Health Research Institute St. Joseph’s Health Care;

    Laboratory of Cellular Biology World Health Collaborating Center for the Development of the Endocrine Pancreas Université Catholique de Louvain;

    Laboratory of Cellular Biology World Health Collaborating Center for the Development of the Endocrine Pancreas Université Catholique de Louvain;

    Laboratory of Cellular Biology World Health Collaborating Center for the Development of the Endocrine Pancreas Université Catholique de Louvain;

    Lawson Health Research Institute St. Joseph’s Health CareDepartment of Medicine University of Western OntarioDepartment of Physiology University of Western OntarioDepartment of Paediatrics University of Western Ontario;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Beta cell; Diabetes; IGF-II; Insulitis; Islet; NOD mouse; Taurine;

    机译:β细胞;糖尿病;IGF-II;胰岛炎;胰岛;NOD小鼠;牛磺酸;

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