The human glucagon-like peptide-1 analogue liraglutide preserves pancreatic beta cells via regulation of cell kinetics and suppression of oxidative and endoplasmic reticulum stress in a mouse model of diabetes

M. Shimoda; Y. Kanda; S. Hamamoto; K. Tawaramoto; M. Hashiramoto; M. Matsuki; K. Kaku

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The human glucagon-like peptide-1 analogue liraglutide preserves pancreatic beta cells via regulation of cell kinetics and suppression of oxidative and endoplasmic reticulum stress in a mouse model of diabetes

机译：人胰高血糖素样肽-1类似物利拉鲁肽在糖尿病小鼠模型中通过调节细胞动力学以及抑制氧化性和内质网应激来保存胰腺β细胞。

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摘要

We investigated the molecular mechanism by which the human glucagon-like peptide-1 analogue liraglutide preserves pancreatic beta cells in diabetic db/db mice.

机译：我们调查了人类胰高血糖素样肽1类似物利拉鲁肽在糖尿病db / db小鼠中保存胰腺β细胞的分子机制。

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来源
《Diabetologia》 |2011年第5期|p.1098-1108|共11页
作者
M. Shimoda; Y. Kanda; S. Hamamoto; K. Tawaramoto; M. Hashiramoto; M. Matsuki; K. Kaku;
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作者单位

Division of Diabetes, Endocrinology and Metabolism, Department of Internal Medicine, Kawasaki Medical School, 577 Matsushima, Kurashiki, Okayama, 701-0192, Japan;

Division of Diabetes, Endocrinology and Metabolism, Department of Internal Medicine, Kawasaki Medical School, 577 Matsushima, Kurashiki, Okayama, 701-0192, Japan;

Division of Diabetes, Endocrinology and Metabolism, Department of Internal Medicine, Kawasaki Medical School, 577 Matsushima, Kurashiki, Okayama, 701-0192, Japan;

Division of Diabetes, Endocrinology and Metabolism, Department of Internal Medicine, Kawasaki Medical School, 577 Matsushima, Kurashiki, Okayama, 701-0192, Japan;

Division of Diabetes, Endocrinology and Metabolism, Department of Internal Medicine, Kawasaki Medical School, 577 Matsushima, Kurashiki, Okayama, 701-0192, Japan;

Division of Diabetes, Endocrinology and Metabolism, Department of Internal Medicine, K;

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关键词
Apoptosis; Beta cell mass; Cellular differentiation; Cellular proliferation; ER stress; Glucagon-like peptide-1; Oxidative stress;

机译：凋亡;β细胞团;细胞分化;细胞增殖;内质网应激;胰高血糖素样肽-1;氧化应激;

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1. The human glucagon-like peptide-1 analogue liraglutide preserves pancreatic beta cells via regulation of cell kinetics and suppression of oxidative and endoplasmic reticulum stress in a mouse model of diabetes [J] . M. Shimoda, Y. Kanda, S. Hamamoto, Diabetologia: clinical and experimental diabetes and metabolism . 2011,第5期

机译：人胰高血糖素样肽-1类似物利拉鲁肽在糖尿病小鼠模型中通过调节细胞动力学以及抑制氧化性和内质网应激来保存胰腺β细胞。
2. The human glucagon-like peptide-1 analogue liraglutide preserves pancreatic beta cells via regulation of cell kinetics and suppression of oxidative and endoplasmic reticulum stress in a mouse model of diabetes [J] . M. Shimoda, Y. Kanda, S. Hamamoto, Diabetologia: clinical and experimental diabetes and metabolism . 2011,第5期

机译：人胰高血糖素样肽-1类似物利拉鲁肽在糖尿病小鼠模型中通过调节细胞动力学以及抑制氧化性和内质网应激来保存胰腺β细胞。
3. Vildagliptin preserves the mass and function of pancreatic β cells via the developmental regulation and suppression of oxidative and endoplasmic reticulum stress in a mouse model of diabetes [J] . Diabetes, obesity & metabolism . 2013,第2期

机译：维格列汀可通过糖尿病小鼠模型中氧化和内质网应激的发育调节和抑制作用来保护胰腺β细胞的质量和功能
4. MOLECULAR CHARACTERIZATION OF ROUGH ENDOPLASMIC RETICULUM SUBPROTEOME IN PANCREATIC BETA CELLS [C] . Jin-sook Lee, Yanning Wu, Patracia Skallos, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2013

机译：胰腺β细胞中粗糙内质网亚颗粒的分子表征
5. Glucagon-like peptide-1 (GLP-1) and liraglutide, a synthetic GLP-1 analog, inhibit inflammation in human aortic endothelial cells via calcium and AMPK dependent mechanisms [D] . Krasner, Nadia Marie 2014

机译：胰高血糖素样肽-1（GLP-1）和Liraglutide，一种合成GLP-1模拟，通过钙和AMPK依赖机制抑制人主动脉内皮细胞中的炎症
6. The human glucagon-like peptide-1 analogue liraglutide preserves pancreatic beta cells via regulation of cell kinetics and suppression of oxidative and endoplasmic reticulum stress in a mouse model of diabetes [O] . M. Shimoda, Y. Kanda, S. Hamamoto, -1

机译：人胰高血糖素样肽-1类似物利拉鲁肽在糖尿病小鼠模型中通过调节细胞动力学以及抑制氧化性和内质网应激来保存胰腺β细胞。
7. The human glucagon-like peptide-1 analogue liraglutide preserves pancreatic beta cells via regulation of cell kinetics and suppression of oxidative and endoplasmic reticulum stress in a mouse model of diabetes [O] . M. Shimoda, Y. Kanda, S. Hamamoto, 2011

机译：人胰高血糖素样肽-1类似物利拉鲁肽在糖尿病小鼠模型中通过调节细胞动力学以及抑制氧化性和内质网应激来保存胰腺β细胞。

The human glucagon-like peptide-1 analogue liraglutide preserves pancreatic beta cells via regulation of cell kinetics and suppression of oxidative and endoplasmic reticulum stress in a mouse model of diabetes

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