The functional and molecular characterisation of human embryonic stem cell-derived insulin-positive cells compared with adult pancreatic beta cells

摘要

Using a novel directed differentiation protocol, we recently generated up to 25% insulin-producing cells from human embryonic stem cells (hESCs) (insulin+ cells). At this juncture, it was important to functionally and molecularly characterise these hESC-derived insulin+ cells and identify key differences and similarities between them and primary beta cells.