Previous Episodes of Hypoglycemic Coma Are Not Associated With Permanent Cognitive Brain Dysfunction in IDDM Patients on Intensive Insulin Treatment

摘要

Intensive insulin treatment of IDDM is associated with increased frequency of hypoglycemic coma. The extent of possible cerebral sequelae after recovery is still unknown. We studied the impact of previous hypogly- cemic coma on neurophysiological measures of cognitive brain function in 108 patients with adult-onset IDDM receiving intensive insulin treatment. In the study, 55 IDDM patients (age 38±14 years, mean ±SD) who had A history of >=1 (median 3, range 1-35) comatose hypo- Glycemic event were compared with 53 IDDM patients (age 34±12 years) with no history of hypoglycemic events using P300 event-related potentials and psy- chometric tests (the Mini-Mental State Exam and trail- making test, part A).