Enhanced De Novo Lipogenesis in the Leptin-Unresponsive Pancreatic Islets of Prediabetic Zucker Diabetic Fatty Rats: Role in the Pathogenesis of Lipotoxic Diabetes

摘要

Overaccumulation of fat in pancreatic islets of obese ZDF/fa/fa rats is believed to cause β-cell failure and dia- Betes. Previously, we demonstrated that ZDF islets Have an increased capacity to esterify fatty acids Imported via the circulation. Here we examine the Capacity of ZDF islets to synthesize fatty acids de novo. Compared with age-matched wild-type (+/+) control Islets, acetly CoA carboxylase (ACC) mRNA was five- Fold and sixfold higher and fatty acid synthetase (FAS) Was fourfold and sevenfold higher in prediabetic and Diabetic ZDF islets, respectively.