Peripheral Neuropathy in Transgenic Diabetic Mice Restoration of C-Fiber Function With Human Recombinant Nerve Growth Factor

摘要

Mice (Ins.D~d1)with hypoinsulinemi diabetes were created by increased expression of syngeneic major hisocompatibility complex (MHC) class I protein in pancreatic β-cells. The diabetic state was characterized In these mice by high glucose concentrations and islet Pathology. To determine whether a neuropathy would Develop, motor and sensory conduction velocities (CV) Were determined in the sciatic nerves of 2-, 4-, and 7- Month-old control and diabetic littermate male mice.