Basal hepatic Glucose Production Is Regulated by the Portal Vein Insulin Concentration

摘要

The ability of portal vein insulin to control hepatic glu- cose production (HGP) is debated. The aim of the pres- ent study was to determine, therefore, if the liver can respond to a selective decrease in portal vein insulin. Isotopic ([~3H]glucose) and arteriovenous difference Methods were used to measure HGP in conscious Overnight fasted dogs. A pancreatic clamp (somato- Statin plus basal portal insulin and glucagon) was used To control the endocrine pancreas. A 40-min control Period was followed by a 180-min test period. During The latter, the portal vein insulin level was selectively Decreased while the arterial insulin level was not Changed.