Brief Genetics Report: Altered β-Cell Characteristics in Impaired Glucose Tolerant Carriers of a GAA Trinucleotide Repeat Polymorphism in the Frataxin Gene

摘要

Friedreich's ataxia is associated with GAA trinu- cleotide repeat expansions in the frataxin gene. In the general population, these trinucleotide expan- sions are variabel in length, and three types of expansions are seen: short, intermediate, and log repeats. Friedreich's ataxia patients are generally homozygous for The long repeats and exhibit diabetes as pronounced comor- Bidity (1,2). Ristow et al. (3) recently reported an association Between the intermediate-length normal allele in the frataxin Gene and type 2 diabetes.