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Genome-Wide Association Scan for Diabetic Nephropathy Susceptibility Genes in Type 1 Diabetes

机译:全基因组关联扫描在1型糖尿病中的糖尿病肾病易感性基因

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摘要

Despite extensive evidence for genetic susceptibility to diabetic nephropathy, the identification of susceptibility genes and their variants has had limited success. To search for genes that contribute to diabetic nephropathy, a genome-wide association scan was implemented on the Genetics of Kidneys in Diabetes collection.
机译:尽管有大量证据表明对糖尿病性肾病的遗传易感性,但对易感性基因及其变异的鉴定却取得了有限的成功。为了寻找有助于糖尿病性肾病的基因,对糖尿病的肾脏遗传学进行了全基因组关联扫描。

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  • 来源
    《Diabetes》 |2009年第6期|p.1403-1410|共8页
  • 作者单位

    Marcus G. Pezzolesi,1 G. David Poznik,1 Josyf C. Mychaleckyj,2 Andrew D. Paterson,3,4 Michelle T. Barati,5 Jon B. Klein,5 Daniel P.K. Ng,1,6 Grzegorz Placha,1,7 Luis H. Canani,1,8 Jacek Bochenski,1 Daryl Waggott,9 Michael L. Merchant,5 B ozena Krolewski,1 Lucia Mirea,4,9 Krzysztof Wanic,1 Pisut Katavetin,1 Masahiko Kure,1 Pawel Wolkow,1,10 Jonathon S. Dunn,1 Adam Smiles,1 William H. Walker,1 Andrew P. Boright,11 Shelley B. Bull,4,9 the DCCT/EDIC Research Group,* Alessandro Doria,1 John J. Rogus,1 Stephen S. Rich,2 James H. Warram,1 and Andrzej S. Krolewski1From the 'Research Division, Joslin Diabetes Center, and Department of Medicine, Harvard Medical School, Boston, Massachusetts, the 2Center for Public Health Genomics, University of Virginia School of Medicine, Charlottesville, Virginia, the ''Program in Genetics and Genome Biology, Hospital for Sick Children, University of Toronto, Toronto, Canada, the ^DaIIa Lana School of Public Health, University of Toronto, Toronto, Canada, "Kidney Disease Program, University of Louisville, Louisville, Kentucky, the "Department of Community, Occupational and Family Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, the department of Hypertension, Medical University of Warsaw, Warsaw, Poland, the department of Endocrinology, Hospital de Curucas de Porto Alegre, Porto Alegre, Brazil, the "Samuel Lunenfeld Research Institute of Mount Sinai Hospital, Prosserman Centre for Health Research, Toronto, Canada, the "TJepartment of Pharmacology, Jagiellonian University, School of Medicine, Krakow, Poland, and the "Department of Medicine, University Health Network, University of Toronto, Toronto, CanadaCorresponding author Andrzej S. Krolewski, andr_ej.krolewst@joslin.harvard.edu Received 31 October 2008 and accepted 23 February 2009.Published ahead of print at http://diabetes.diabetesjournals.org on 27 February 2009. DOL 10.2337/db08-1514.* Study group members for the Diabetes Control and Complications Trial/ Epidemiology of Diabetes Interventions and Complications Research Group are listed in N Engl J Med 2005,353:2643-2653.© 2009 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by -nc-nd/3.0/ for details.The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked "aduertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.,;

  • 收录信息 美国《科学引文索引》(SCI);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
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  • 入库时间 2022-08-17 13:45:55

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