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Interrogating Type 2 Diabetes Genome-Wide Association Data Using a Biological Pathway-Based Approach

机译：使用基于生物途径的方法询问2型糖尿病基因组范围的关联数据

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摘要

Recent genome-wide association studies have resulted in a dramatic increase in our knowledge of the genetic loci involved in type 2 diabetes. In a complementary approach to these single-marker studies, we attempted to identify biological pathways associated with type 2 diabetes. This approach could allow us to identify additional risk loci.
机译：最近的全基因组关联研究已导致我们对2型糖尿病涉及的基因位点的了解大大增加。在对这些单标记研究的补充方法中，我们试图确定与2型糖尿病相关的生物学途径。这种方法可以使我们确定其他风险位点。

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  • 来源
    《Diabetes》 |2009年第6期|p.1463-1467|共5页
  • 作者

    John R B Perry Mark I McCarthy Andrew T Hattersley Eleftheria Zeggini Michael N Weedon Timothy M Frayling;

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    John K.B. Perry,1 Mark I. McCarthy,2,3 Andrew T. Hattersley,1 Eleftheria Zeggini,2 the Wellcome Trust Case Control Consortium, Michael N. Weedon,1 and Timothy M. Frayling1From 1 Genetics of Complex Traits, Institute of Biomedical and Clinical Science, Peninsula Medical School, Magdalen Road, Exeter, U.K., the 2 Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, U.K., and the 3 Oxford Centre for Diabetes, Endocrinology and Medicine, University of Oxford, Churchill Hospital, Oxford, U.K.Corresponding author: Michael Weedon, michael.weedon@pms.ac.uk.Received 7 October 2008 and accepted 18 February 2009.Published ahead of print at http://diabetes.diabetesjournals.org on 27 February 2009. DOI: 10.2337/db08-1378.© 2009 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section i734 solely to indicate this fact.,;

  • 收录信息 美国《科学引文索引》(SCI);美国《化学文摘》(CA);
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  • 正文语种 eng
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  • 入库时间 2022-08-17 13:45:54

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