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Mechanisms of Podocyte Injury in Diabetes: Role of Cytochrome P450 and NADPH Oxidases

机译：糖尿病足细胞损伤的机制：细胞色素P450和NADPH氧化酶的作用

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摘要

We investigated the role of cytochrome P450 of the 4A family (CYP4A), its metabolites, and NADPH oxidases both in reactive oxygen species (ROS) production and apoptosis of podocytes exposed to high glucose and in OVE26 mice, a model of type 1 diabetes.
机译：我们研究了4A家族的细胞色素P450（CYP4A），其代谢产物和NADPH氧化酶在暴露于高葡萄糖的OVE26小鼠和1型糖尿病模型中的活性氧（ROS）产生和足细胞凋亡的作用。

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  • 来源
    《Diabetes》 |2009年第5期|p.1201-1211|共11页
  • 作者

    A Eid Yves Gorin Bridget M Fagg Rita Maalouf Jeffrey L Barnes Karen Block Hanna E Abboud;

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    Assaad A. Eid,1 Yves Gorin,1 Bridget M. Fagg,1 Rita Maalouf,1 Jeffrey L. Barnes,1,2 Karen Block,1,2 and Hanna E. Abboud1,2From the 'University of Texas Health Science Center, Department of Medicine, San Antonio, Texas, and the 2South Texas Veterans Healthcare System, San Antonio, Texas.Corresponding author: Hanna E. Abboud, abboud@uthscsa.edu.Received 4 November 2008 and accepted 5 February 2009.Published ahead of print at http://diabetes.diabetesjournals.org on 10 February 2009. DOI: 10.2337/db08-1536.© 2009 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by -nc-nd/3.0/ for details.The costs of publication of this artiste were defrayed in part by the payment of page charges. This article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 17?4 solely to indicate this fact.,;

  • 收录信息 美国《科学引文索引》(SCI);美国《化学文摘》(CA);
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