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Functional Characterization of Promoter Variants of the Adiponectin Gene Complemented by Epidemiological Data

机译：脂联素基因启动子变异的功能特征与流行病学数据的补充

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摘要

Adiponectin (APM1, ACDC) is an adipocyte-derived protein with downregulated expression in obesity and insulin-resistant states. Several potentially regulatory single nucleotide polymorphisms (SNPs) within the APM1 gene promoter region have been associated with circulating adiponectin levels. None of them have been functionally characterized in adiponectin-expressing cells. Hence, we investigated three SNPs (rs16861194, rs17300539, and rs266729) for their influence on adiponectin promoter activity and their association with circulating adiponectin levels.
机译：脂联素（APM1，ACDC）是一种来自脂肪细胞的蛋白质，在肥胖和胰岛素抵抗状态下表达下调。 APM1基因启动子区域内的几种潜在的调节性单核苷酸多态性（SNP）已与循环脂联素水平相关联。它们均未在表达脂联素的细胞中进行功能鉴定。因此，我们研究了三种SNP（rs16861194，rs17300539和rs266729）对脂联素启动子活性的影响以及与循环脂联素水平的关系。

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  • 来源
    《Diabetes》 |2009年第4期|p.984-991|共8页
  • 作者

    Helmut Laumen Akuma D Saningong Iris M Heid Jochen Hess Christian Herder Melina Claussnitzer Jens Baumert Claudia Lamina Wolfgang Rathmann Eva-Maria Sedlmeier Norman Klopp Barbara Thorand H-Erich Wichmann Thomas Illig Hans Hauner;

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    Helmut Laumen,1 Akuma D. Saningong,1 Iris M. Heid,2'3 Jochen Hess,4 Christian Herder,5 Melina Claussnitzer,1 Jens Baumert,2 Claudia Lamina,2 Wolfgang Rathmann,6 Eva-Maria Sedlmeier,1 Norman Klopp,2 Barbara Thorand,2 H.-Erich Wichmann,2'3 Thomas Illig,2 and Hans Hauner1From the 'Else Kröner-Fresenius-Center for Nutritional Medicine, Technische Universität München, Munich, Germany, 2Helmholtz Zentrum München, German Research Center for Environmental Health, Institute of Epidemiology, Neuherberg, Germany, the "Institute of Medical Information Processing, Biometry and Epidemiology, Ludwig-Maximilians University Munich, Munich, Germany, the 4Division of Signal Transduction and Growth Control, German Cancer Research Center, Heidelberg, Germany, the 5Institute for Clinical Diabetology, German Diabetes Center, Leibniz Institute at Heinrich-Heine-University, Düsseldorf, Germany, and the 6Institute of Biometrics and Epidemiology, German Diabetes Center, Leibniz Institute at Heinrich-Heine-University, Düsseldorf, Germany.Corresponding author: H. Laumen, helmut.laumen@wzw.tum.de.Received 26 November 2007 and accepted 30 November 2008.Published ahead of print at http://diabetes.diabetesjournals.org on 15 December 2008. DOI: 10.2337/db07-1646.T.I. and H.H. contributed equally to this work.© 2009 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/Ucenses/by -nc-nd/3.0/ for details.The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.,;

  • 收录信息 美国《科学引文索引》(SCI);美国《化学文摘》(CA);
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  • 入库时间 2022-08-17 13:45:51

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