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首页> 外文期刊>Diabetes >Transgenic Restoration of Long-Chain n-3 Fatty Acids in Insulin Target Tissues Improves Resolution Capacity and Alleviates Obesity-Linked Inflammation and Insulin Resistance in High-Fat-Fed Mice
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Transgenic Restoration of Long-Chain n-3 Fatty Acids in Insulin Target Tissues Improves Resolution Capacity and Alleviates Obesity-Linked Inflammation and Insulin Resistance in High-Fat-Fed Mice

机译：胰岛素靶组织中长链n-3脂肪酸的转基因恢复提高了分辨能力并减轻了肥胖小鼠的肥胖相关性炎症和胰岛素抵抗

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摘要

The catabasis of inflammation is an active process directed by n-3 derived pro-resolving lipid mediators. We aimed to determine whether high-fat (HF) diet-induced n-3 deficiency compromises the resolution capacity of obese mice and thereby contributes to obesity-linked inflammation and insulin resistance.
机译：炎症的催化作用是由n-3衍生的促分解脂质介体指导的一个活跃过程。我们旨在确定高脂（HF）饮食诱导的n-3缺乏症是否会损害肥胖小鼠的分辨能力，从而导致肥胖相关的炎症和胰岛素抵抗。

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  • 来源
    《Diabetes》 |2010年第12期|p.3066-3073|共8页
  • 作者

    Phillip J White Makoto Arita Ryo Taguchi Jing X Kang André Marette;

  • 作者单位

    Phillip J. White,1 Makoto Arita,2 Ryo Taguchi,3 Jing X. Kang,4 and André Marette1From the 'Department of Medicine, Faculty of Medicine, Cardiology axe, Quebec Heart and Lung Institute, CHUQ Research Centre, and LNAF, Laval University, Quebec, Canada, the department of Health Chemistry, Graduate School of Pharmaceutical Sciences, University of Tokyo, Tokyo, Japan, the ''Department of Metabolome, Graduate School of Medicine, University of Tokyo, Tokyo, Japan, and the 4Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.Corresponding author André Marette, andre.marette@crchul.ulaval.ca.Received 13 January 2010 and accepted 26 August 2010. Published ahead of print at http://diabetes, diabetesjournals.org on 14 September 2010. DOI: 10.2337/db 10-0054.© 2010 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by -nc-nd/3.0/ for details.The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked "advertisement." in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.,;

  • 收录信息 美国《科学引文索引》(SCI);美国《化学文摘》(CA);
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  • 正文语种 eng
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  • 入库时间 2022-08-17 13:45:43

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