Adipocyte Metabolism in Adipocyte Fatty Acid Bindign Protein Knockout (aP2~-/-) Mice After Short-Term High-Fat Feeding

摘要

Mice null for adipocyte fatty acid binding protein (AFABP) compensate by increasing expression of ker- atinocyte fatty acid binding protein (KFABP) (Hotamis- ligil et al. Science 274:1377-1397, 1996). In the present study, AFABP knockout 9KO) and wild-type (WT) mice became equally obese on a high-fat diet, as judged by fat pad weights, adipocyte size, and body composition analysis. High-fat feeding led to moderate insulin resistance in both WT and AFABP knockout mice, as indicated by an ～2-fold increase in plasma insulin.