Response of Pancreatic β-Cells to Improved Insulin Sensitivity in Women at High Risk for Type 2 Diabets

摘要

The purpose of this study was to examine the response of pancreatic β-cells to changes in insulin sensitivity in women at high risk for type 2 diabetes. Oral glucose tol- erance tests (OGTTs) and frequently sampled intra- venous glucose tolerance tests FSIGTs) were con- ducted on Latino women with impaired glucose toler- ance and a history of gestational diabetes before and after 12 weeks of treatment with 400 mg/day troglita- zone (n=13) or placeob (n=12)/