β-cell dysfunction and failure in type 2 diabetes potential mechanisms

摘要

Type 2 diabetes is characterized by a progressive loss of β-cell function throughout the course of the disease. The pattern of loss is an initial defect in early or first- Phase insulin secretion, followed by a decreasing max- Imal capacity of glucose to potential all nonglucose sig- Nals. Last, a defective steady-state and basal insulin Secretion develops, leading to complete β-cell failure Requiring insulin. Treatment. This functional loss Exceeds the expected impact of a 20-50/100 loss of β-cells Reported at autopsy, which has been associated with Amyloid deposits.