Effect of antioxidant treatment of streptozotocin-induced diabetic rats on endoneurial blood flow, motor nerve conduction velocity, and vascular reactivity of epineurial arterioles of the sciatic nerve

摘要

We have shown that diabetes-induced reduction in en- doneurial blood flow(EBF)and impaired endothelium- dependent vascular relatxation precede slowing of motor nerve conduction velocity(MNCV)and decreased sci- atic nerve Na~+/K~+ ATPase activity. Furthermore, vascu- lar dysfunction was accompanied by an accumulation of superoxide in arterioles that provide circulation to the sciate nerve. In the present study, we examined the effect that treatment of streptoxotocin-induced diabetic rats with antioxidants has on vascular and neural func- tion.