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Liver-derived IGF-I is of importance for normal carbohydrate and lipid metabolism

机译:肝源性IGF-I对于正常碳水化合物和脂质代谢至关重要

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摘要

IGF-I is important for postnatal body growth and exhib- its insulin-like effects on carbohydrate metabolism. The function of liver-derived IGF-I is still not established, although we previously demonstrated that liver-derived IGF-I is not required for postnatal body growth. Mice Whose IGF-I gene in the liver was inactivated at 24 days Of age were used to investigate the long-term role of Liver-derived IGF-I for carbohydrate and lipid metabo- Lism. Serum levels of leptin in these mice were increased By > 100/100 at 3 months of age, whereas the fat mass of The mice was decreased by 25/100 at 13 months of age.
机译:IGF-I对于出生后的身体生长及其对碳水化合物代谢的类胰岛素作用非常重要。肝源性IGF-I的功能仍未确立,尽管我们之前已证明肝源性IGF-I并非出生后身体生长所必需的。肝脏中IGF-I基因在24日龄时失活的小鼠被用于研究肝脏衍生的IGF-I对碳水化合物和脂质代谢的长期作用。这些小鼠的血清瘦素水平在3个月大时增加了> 100/100,而在13个月大时,小鼠的脂肪量减少了25/100。

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