The novel imidazoline compound BL11282 potentiates glucose-induced insulin secretion in pancreatic β-cells in the absence of modulation of K_ATP channel activity

摘要

The insulinotropic activity of the novel imidazoline com- pound BL11282 was investigated. Intravenous adminis- tration of BL11282(0.3 mg.kg~-1. min~-1)to anesthetized rats did not changes blood glucose and insulin levels un- der basal conditions, but produced a higher increase in blood insulin levels and a faster glucose removal from the blood after glucose infusion. Similarly, in isolated Wistar rat pancreatic islets, 0.1-100 μ-mol/l BL11282 Potently stimulated glucose-induced insulin secretion But did not modulate basal insulin secretion.