Autoantibody response to CD38 in caucasian patients with type 1 and type 2 diabetes: immunological and genetic characterization

摘要

Insulin secretion is one of the functions mediated by CD38, a nonlineage pleiotopic cell surface receptor. The molecule is the target of an autoimmune response, Because serum autoantibodies(aAbs)to CD38 have Been detected in diabetic patients. In the healthy Cau- Casian population, the CD38 gene is bi-allelic(86/100 CD38*B and 14/100 CD38*A), whereas an Arg~140 Trp mu- Tation has been identified in Japanese diabetic patients.