Glucokinase gene locus transgenic mice are resistant to the development of obesity-induced type 2 diabetes

摘要

Transgenic mice that overexpress the entire glucoki- nase(GK)gene locus have been previously shown to be midly hypoglycemic and to have improved tolerance to glucose. To determine whether increased GK might also prevent or diminish diabetes in diet-induced obese ani- mals, we examined the effect of feeding these mice a high-fat high-simple carbohydrate low-fiber diet(HF diet)for 30 weeks. In response to this diet, both normal and transgenic mice became obese and had similar BMIs (5.3±0.1 and 5.0±0.1 kg/m~2)in transgenic and non- transgenic mice, respectively.