A distinct th1 immune response precedes the described th2 response in islet xenograft rejection

摘要

Previous studies using semiquantitative reverse tran- scription-polymerase chain reaction(RT-PCR)have demonstrated that islet xenograft rejection in mice is dominated by Th2-associated cytokines, i.e., interleukin (IL)-4 and IL-10. However, immunohistochemical stain- ings show that the morphological pattern in this model is more reminiscent of a delayed-type hypersensitivity (DTH)reaction, which is associated with a Th1 re- sponse. This study was designed to resolved the mecha- nisms of acute cellular xenograft rejection in rats transplanted with fetal porcine islet-like cell clusters (ICCs).