Exploring the Promise of Resveratrol: Where Do We Go From Here?

摘要

Resveratrol (3,5,4'-trihydroxystilbene), a plant-derived polyphenol and activator of the mammalian sirtuin, SIRT1, has demonstrated promising effects on glucose metabolism in rodent models (1). However, despite the widespread use of resveratrol as a nutritional supplement and the many health claims made on its behalf, data from human studies are extremely limited. Here, we explore why, in contrast to many studies in mammalian models, the article by Poulsen et al. (2) in this issue of Diabetes reports that chronic high doses of resveratrol have no demonstrable metabolic effects.