Impact of ER Protein Homeostasis on Metabolism

摘要

Proper regulation of protein homeostasis in a cell is critical for the health of the organism. Proteins, intracellular or secreted, need to be produced and maintained at the right quantity, folded into their three-dimensional conformation with necessary posttranslational modifications, targeted to their correct destinations to insure their optimal function, and degraded efficiently and disposed when needed. The overall process is tightly regulated at many levels to increase or decrease the rate of the synthesis and breakdown of polypeptides. In most cases, failure to properly regulate any one of these control points leads to a dysfunction at the cellular and organismic level resulting in disease.