Editorial: Targeting Neuroinflammation in Central Nervous System Disorders: Uncovering Mechanisms, Pharmacological Targets, and Neuropharmaceutical Developments

摘要

In this special issue we present a series of reviews and research papers written from leading authors highlighting neuroinflammation as a common target to overcome and understand brain disorders. Neuroinflammation plays a key role in Parkinson, Alzheimer, schizophrenia, major depression and drug addiction, among others. Some threads include: autophagic dysfunction (essential for the removal of unnecessary cellular constituents and dysfunctional components), dysfunctional central nervous system (CNS) lymphatic drainage (dampened cleansing of molecules prone to aggregation and reduced immune cell egress into the draining cervical lymphatic nodes), traumatic brain injury and psychostimulants and alcohol abuse disorders. The growing evidence shows that attenuation of neuroinflammation brings beneficial effects against neurodegeneration and cognitive deficits associated with a plethora of CNS disorders. Considering this last issue, the identification of its most relevant biological processes and possible pharmacological targets remains a major challenge.