IGF-1 Rs5742632 Snps in Mandibular Asymmetry Adult Patients at Dental Hospital Universitas Sumatera Utara

摘要

The aimed of study to analysis the IGF-1 rs5742632 Single-nucleotide polymorphisms (SNPs) based on the severity of mandibular asymmetry. This is a cross-sectional study of genotypefenotype study of IGF-1 rs5742632 SNPs and mandibular asymmetry. There were 60 pretreatment adult orthodontic medical record that was included in this study. The mandibular asymmetry was measured in panoramic radiographs with Lemos method. The SNPs of IGF-1 rs5742632 analysis was performed based on polymerase chain reaction – restriction fragment polymorphisms (PCR-RFLP). The test of genotype distribution and allele frequency for significance by using the Chi square- test followed by Hardy-Weinberg Equilibrium calculation. There were twenty subjects (33.3%) of TT, eleven subjects (18.33%) of CC, and twenty nine subjects (48.33%) of TC with the meant age of 21.71 ± 2.31 year old. There was a significant difference (p<0.05) IGF-1 rs5742632 polymorphism among light, moderate, and severe mandibular asymmetry. The analysis framework of modeling mandibular asymmetry severity from DNA polymorphism can contribute the assessment of feasibility and psychological acceptability the genetic screening to change clinician’s management mindset in the orthodontics primary care setting.