The Status of Local Immunity and Biocenosis of the Oral Cavity After the Removal of Wisdom Teeth Against the Background of Phage Therapy

摘要

This article examines the qualitative and quantitative composition of the oral microbiota after the impacted lower wisdom teeth removal. A significant bacterial growth was noted, which is manifested by a shift in the equilibrium of the oral biocenosis towards the pathogenic flora with a predominance of facultative anaerobes. The dynamics of changes in microflora against the background of antibacterial treatment and phage therapy is described. Multidirectional changes in the indices of local immunity were also established against the background of antibacterial treatment and phage therapy, which indicated a decrease in the activity of inflammation due to the elimination of pathogens. The obtained data confirm the clinical, bacteriological and immunological effectiveness of oral phage therapy for inflammatory diseases in dental practice and can serve as the basis for the development of a new algorithm for the use of bacteriophages in the treatment of purulent-inflammatory diseases of the oral cavity.