A Quick Approach for Evaluation of Drug-Excipient Compatibility: Case of Acetylsalicylic Acid

摘要

Drug-excipient compatibility testing is one of the early formulation screening steps that can help predict a drug product’s stability. Conventional methods for compatibility testing however, are time consuming, labor intensive, require screening several excipients and eventually different formulations. For instance, HPLC analysis is often used for compatibility testing taking many weeks if not months to generate data as various blends are held at accelerated conditions.