Mitochondrial Dysfunction in Astrocytes: A Role in Parkinson’s Disease?

摘要

Mitochondrial dysfunction is a hallmark of Parkinson's disease (PD). Astrocytes are the most abundant glial cell type in the brain and are thought to play a pivotal role in the progression of PD. Emerging evidence suggests that many astrocytic functions, including glutamate metabolism, Ca2 signaling, fatty acid metabolism, antioxidant production, and inflammation are dependent on healthy mitochondria. Here we review how mitochondrial dysfunction impacts astrocytes, highlight translational gaps, and open new questions for therapeutic development.