PROTECTIVE EFFECT OF CINNAMOMUM ZEYLANICUM BARK AGAINST ACETAMINOPHEN INDUCED HEPATOTOXICITY IN ALBINO RATS

摘要

The objective of the current study is to investigate the hepatoprotective activity of Cinnamomum zeylanicum bark (CZB) extract on acetaminophen-induced hepatotoxicity in albino rats. Wistar albino rats (150-200 g) of either sex were divided into six groups, and toxicity was induced by acetaminophen (APAP) at a dose of 750 mg/kg, bw, p.o, every 72 h, for two weeks. Silymarin (100 mg/kg, p.o) was given as reference standard. CZB (100 mg/kg and 200 mg/kg, p.o) was tested for hepatoprotective activity. Various serum parameters like alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatise (ALP), total Bilirubin (TB), total protein (TP), albumin (ALB), and total cholesterol (TC) in different groups were measured. Further, the effect of the extract on super oxide dismutase, catalase, reduced glutathione, and lipid peroxidation were also estimated. The treatment with ethanolic extract of CZB reduced the elevated levels of AST, ALT, ALP, TB, and TC and also reversed the hepatic damage as compared with toxic control rats. A decreased level of ALB and TP was also significantly restored by CZB pre-treatment. It is also significantly restored the antioxidant level in hepatic tissue. Further CZB treatment also reduced histological alteration induced in the liver. The result suggests that the ethanolic extract of CZB has strong hepatoprotective agents on acetaminophen-induced toxicity in albino rats.