COMPARATIVE STUDY ON THE PHARMACOKINETICS OF IBUPROFEN ALONE OR IN COMBINATION WITH PIPERINE AND ITS SYNTHETIC DERIVATIVES AS A POTENTIAL BIOENHANCER

摘要

Ibuprofen has a higher dose (2000-2400 mg/day) that leads to several adverse effects like stomach upset, headache, bloating, hyperacidity, diarrhea, nausea, constipation, mild heartburn, ringing in your ears, vomiting and blurred vision. Piperine is a natural alkaloid obtained from piper species, principally from Piper longum and Piper nigrum (Family: Piperaceae). Piperine demonstrates excellent bioavailability Enhancing activity of different xenobiotics. Here in this study, the synergistic effect of Piperine and its synthesized derivatives was studied. Ibuprofen (10 mg/kg), in combination with Piperine and its derivatives (5a-5d) (10 mg/kg, were administered to Wistar rats, and the pharmacokinetic parameters were estimated. Thus, the study concludes that the presence of 5a significantly increases the absorption and reduces the elimination of the drug from the body.