ANTIHYPERGLYCAEMIC AND ANTIOXIDANT ACTIVITY OF METHANOLIC EXTRACT OF CAPPARIS DECIDUA (FORSSK.) EDGEW. IN STREPTOZOTOCIN-INDUCED DIABETIC RATS

摘要

The present study evaluates the antihyperglycaemic and antioxidant activity of the methanolic extract of Capparis decidua (CDMtE) fruits in streptozotocin (STZ) induced diabetic rats. Streptozotocin (50mg/kg body weight/) was injected intraperitoneally in rats to induce diabetes. The STZ-induced diabetic rats were treated with CDMtE (200 mg/kg body weight /day) for seven days. Biochemical analysis, toxicity studies, and histopathological studies were carried out to assess the antihyperglycaemic and antioxidant effects. Treatment with CDMtE (200 mg.kg b.wt/day) caused a significant decrease in fasting blood glucose and improvement in the serum insulin level of the diabetic rats. Antioxidant enzymes SOD and GSH activity was increased, and LPO levels of diabetic rats decreased after oral administration of CDMtE (200 mg/kg body weight/day). Histopathological studies showed significant recovery in liver architecture after CDMtE administration. Histopathological results suggest the antihyperglycaemic and antioxidant ability of CDMtE. This study supports the therapeutic potential of C.decidua fruits in the treatment of diabetes.