Association of uncoupling protein-2 -866G/A and Ala55Val polymorphisms with susceptibility to type 2 diabetes mellitus

摘要

Background: Recently, the relationships between uncoupling protein-2 (UCP2) -866G/A (rs659366) and Ala55Val (rs660339) polymorphisms and the risk of type 2 diabetes mellitus (T2DM) have been explored considerably, but the results are greatly inconsistent. This meta-analysis was performed to further identify the association of UCP2 rs659366 and rs660339 with the risk of T2DM. Methods: Eligible studies were searched from PubMed, Embase, Cochrane Library, VIP database, Chinese National Knowledge Infrastructure, and Chinese WanFang database until March 8, 2020. The odds ratios with corresponding 95% confidence intervals (CIs), and P-values were used to assess the strength of the association. Results:A total of 26 studies were included in this study. UCP2 rs659366 was associated with the risk of T2DM in allele model (OR: 1.112, 95%CI: 1.009-1.224, P=0.032), dominant model (OR: 1.189, 95%CI: 1.035–1.366, P=0.014), and heterozygous model (OR: 1.177, 95%CI: 1.032–1.342, P=.015). A significantly increased risk of T2DM was detected in Asians by UCP2 rs659366 allele (OR: 1.132, 95%CI: 1.016–1.262, P=.025), dominant (OR: 1.218, 95%CI: 1.046–1.418, P=.011), homozygous (OR: 1.254, 95% CI: 1.022–1.540, P=.031) or heterozygous (OR: 1.198, 95%CI: 1.047–1.371, P=.009) models. There was no significant correlation between UCP2 rs660339 and the risk of T2DM (P.05). Conclusions: The UCP2 rs65366 is significantly associated with the risk of T2DM, especially in Asian population, while no evidence is found between the UCP2 rs660339 and the susceptibility to T2DM. Abbreviations: ATP = adenosine triphosphate, CIs = confidence intervals, NOS = Newcastle-Ottawa scale, PCR-RFLP = polymerase chain reaction–restriction fragment length polymorphism, rs659366 = -866G/A, rs660339 = Ala55Val, T2DM = type 2 diabetes mellitus, UCP2 = uncoupling protein-2.