Bacteria make surgical strikes on host ubiquitin signaling

摘要

Ubiquitin signaling is an essential eukaryotic posttranslational modification that regulates a gamut of cellular processes ranging from a classical role in proteasomal degradation to emerging roles in autophagy and immunity. Its breadth of signaling roles stems from the unique ability of ubiquitin to be assembled into complex poly-ubiquitin chains through any of 7 lysine residues or the amino terminus. Identifying the regulators and signaling outcomes of each type of poly-ubiquitin chain is an active area of research, but the emerging theme thus far is that distinct cellular messages are encoded in each linkage form [1].