Multiple Primary Malignant Tumors of the Female Reproductive System as the Risk Indicators for Oncopathologies Development

摘要

The aim of the research was to study the frequency of development of synchronous and metachronous tumors, as well as the combination of various types of cancer among patients with primary multiple malignant tumors of the female reproductive system, which is important for improving the diagnosis of this category of patients. Material and methods. 80 patients with multiple primary malignant tumors with lesions of the female reproductive system (II-III clinical stages of the disease) were included in the study. Results. In our studies, synchronous tumors were found in 22 (27.5%), and metachronous tumors – in 58 (72.5%) patients. 9 (23.7%) from 38 patients with breast cancer were diagnosed with synchronous cancer of the second breast, and 3 (7.9%) were diagnosed with ovarian cancer. At the same time, synchronous breast cancer was detected in 5 (22.7%) of 22 patients with primary ovarian cancer, in 3 (25.0%) of 12 patients with uterine body cancer and in 2 (25.0%) of 8 patients with cervical cancer. Metachronous tumors were diagnosed in 26 (68.4%) patients with breast cancer, in 17 (77.3%) with ovarian cancer, in 9 (75.0%) with uterine body cancer and in 6 (75.0%) patients with cervical cancer. The most often metachronous tumors were detected in the period from 6 months to 1 year and from 1 year to 2 years in 26 (44.8%) patients. Conclusion. Thus, each of the female reproductive system tumors should be considered as an indicator of other oncopathologies risk. And effective dispensary monitoring will allow to monitor the development of multiple primary malignant tumors in this type of patients in advance.