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首页> 外文期刊>American Journal of Translational Research >Clinical significance of sFRP5, RBP-4 and NT-proBNP in patients with chronic heart failure
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Clinical significance of sFRP5, RBP-4 and NT-proBNP in patients with chronic heart failure

机译：慢性心力衰竭患者SFRP5，RBP-4和NT-PROPNP的临床意义

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Objective: This study was designed to investigate the levels and clinical significance of secretory frizzled-related protein 5 (sFRP5), retinol binding protein 4 (RBP-4) and N-terminal (NT)-pro hormone BNP (NT-proBNP) in patients with chronic heart failure (CHF). Methods: Eighty-nine patients with CHF treated in our hospital were included as the observation group. Seventy-five healthy volunteers who underwent physical examination in our hospital during the same period were selected as the control group. The subjects in the observation group were divided into NYHA class II (n=23), NYHA class III (n=34) and NYHA class IV (n=32) according to NYHA classification, and the levels of sFRP5, RBP-4 and NT-proBNP as well as left ventricular end-diastolic diameter (LVEDD) and left ventricular ejection fraction (LVEF) were compared in the three groups. Spearman correlation was used to analyze the relationship between sFRP5, RBP-4, NT-proBNP and LVEDD, LVEF. The ROC curves of sFRP5, RBP-4 and NT-proBNP for the diagnosis of CHF were plotted. Patients in the observation group were divided into a death group (n=30) and a survival group (n=59) according to the 1-year follow-up outcome, and the levels of sFRP5, RBP-4, and NT-proBNP were compared between the two groups. Results: The observation group showed significantly higher levels of sFRP5, RBP-4, NT-proBNP and LVEDD, and a significantly lower level of LVEF than the control group. Spearman’s correlation analysis showed that sFRP5, RBP-4, NT-proBNP were correlated with LVEDD and LVEF in CHF patients ( P 0.05). The ROC curve showed that the AUC of sFRP5, RBP-4 and NT-proBNP for CHF diagnosis were 0.9378, 0.9133, and 0.9375, respectively. sFRP5, RBP-4, and NT-proBNP in the death group were all higher than those in the survival group ( P 0.05). Conclusion: sFRP5, RBP-4, and NT-proBNP showed a close correlation with CHF. It is worthy of using this method as a clinical index for the diagnosis and prognosis of CHF.
机译：目的：本研究旨在探讨分泌物混发相关蛋白5（SFRP5），视黄醇结合蛋白4（RBP-4）和N-末端（NT）-PRO激素BNP（NT-PROPNP）的水平和临床意义患者慢性心力衰竭（CHF）。方法：在我们院内治疗的89例CHF患者作为观察组。在同一期间在同一时期进行医院进行体检的七十五的健康志愿者被选为对照组。观察组中的受试者分为NYHA类II（n = 23），奈赫级III（n = 34）和NYHA类IV（n = 32），根据NYHA分类，以及SFRP5，RBP-4和在三组比较NT-probNP以及左心室舒张直径（LVEDD）和左心室喷射分数（LVEF）。 Spearman相关性用于分析SFRP5，RBP-4，NT-PROPNP和LVEDD，LVEF之间的关系。绘制了SFRP5，RBP-4和NT-PROPNP的ROC曲线，用于诊断CHF。观察组的患者分为死亡组（n = 30）和根据1年后续结果的生存组（n = 59），以及SFRP5，RBP-4和NT-PROPNP的水平比较两组之间。结果：观察组显示出较高水平的SFRP5，RBP-4，NT-PROPNP和LVEDD，而且比对照组明显较低的LVEF水平。 Spearman的相关性分析表明，SFRP5，RBP-4，NT-probNP与CHF患者中的LVEDD和LVEF相关（P <0.05）。 ROC曲线表明，SFRP5，RBP-4和NT-PROPNP的AUC分别为0.9378,0.9133和0.9375。死亡组中的SFRP5，RBP-4和NT-probnp全部高于存活组中的NT-probnp（P <0.05）。结论：SFRP5，RBP-4和NT-PROPNP显示与CHF紧密相关。值得使用这种方法作为CHF诊断和预后的临床指标。

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