Immunomodulatory function of the active ingredients in traditional Chinese prescriptions on early stage esophageal cancer with dysplasia

摘要

Objective: To explore the effects of the ingredients in a traditional Chinese prescription on the immune regulation of esophageal cancer in patients with early atypical hyperplasia. Methods: A total of 60 C57BL mice were randomly selected as the positive control group; another 240 C57BL mice were randomly divided into a blank control group (n=30), a 4NQO group (n=60) and an experimental group (n=120). The experimental group was divided into the prevention group which received carcinogens and the prescription composition simultaneously, and the treatment group which received carcinogens first and the prescription composition second. The lymphocyte proliferation responses in peripheral blood and spleen cells were determined, and the changes of CD4 + , CD8 + , B7H4, CD4 + CD25 + before and after administration were measured. Results: The CD4 + cell concentration in the 4NQO group was significantly higher than that in the other four groups ( P 0.05); the CD8 + concentration in the 4NQO and the prevention groups was significantly higher than that in the other three groups ( P 0.05). Conclusion: The composition of traditional Chinese prescriptions can improve antitumor immunity and slow down the development of esophageal precancerous lesions by inhibiting the expression of T cells on lymphocytes and the positive expression of B7H4 and CD4 + in esophageal cancer.