Mitochondrial Inner Optic Atrophy 1 (opa1) Gene is Necessary for Regulating and Activating Lysosome, related Orphan Receptor a (rora) Genes, and Apol1 Gene Involved in Autophagy Cells for AntiInflammation Processes, where ror-Rlpha Genes Stored as Lysosomal Security Granules within Autophagy Cells

摘要

Tumor Necrosis Factor alpha (TNF-α) subunits deficiency or the involvement in will lead to Sickle Cell Disease(SCD) which marked by a phenotypic variability and inflammation plays the major role in SCD pathophysiology,which linked strongly to RORA1 genes expression and functions, and also linked to TNF-α subunits expressionsand. Activities, where TNF-α subunits are so essential for anti-inflammation processes and linked to ROR-αgenes activities and functions, and necessary for regulation of bone homeostasis in several chronic immune andinflammatory joints and tissues diseases.The inhibition of TNFα due to inhibition or variations in ROR-alpha genes lead d to significant inflammationsimprovements involved in SCD pathophysiology , and also will lead to increasing in Nuclear Factor-κB pathways(NFκB) catabolic pathways and any remaining of TNF-α will be involved in the NF-κB signaling pathway due toinhibition in their mitochondrial activities.The inhibition or deficiency in presence of Thymine in the Related Orphan Receptor-A (RORA) genes can reflectdeficiency in mitochondrial synthetase enzyme (where mitochondrial OPA1 gene depending on ribosomal genes- ctions in TNF -α, TXA2, and in VEGF-A subunits.RORA genes necessary for lipid metabolism where is controlled by mitochondrial phospholipase enzymesproductions, similarly, -αGenes is necessary for promotion and regulations of hepatic glucose metabolism and isnecessary for hepatic activities and for sestrin-Leu carrier synthesis and activities during hepatic metabolic activities.-α genes are having so necessary functions of preventing G-protein aggregates associated withneuropathies, and preventing blood platelets aggregations depending on mitochondrial activities through producingits active inflammatory enzymes for acting on any toxic inflammation or on any aggregation for producing the activeTXA2 subunits which through feedback will reforme VEGF-A alpha subunits where can be stored in or as lysosomalsecretory granules.