Problem: Depression is spreading rapidly worldwide. It has been forecasted to become the leading cause of disability worldwide by 2030, despite significant efforts and investments made to treat it. This menace has been exacerbated by the current COVID-19 pandemic which has triggered psychological distress and a surge in experiences of emptiness, sadness, and loss of meaning in life. Meaninglessness is one of the biggest threats of our times and is associated with depression and suicide. Gap: Existential psychotherapy has been neglected by researchers and remains misunderstood by the new generation of clinicians as an integrative approach to the prevention and treatment of depression, despite being one of the longest-established forms of psychotherapy. Objective: To address the above gap, recommendations, and emerging risks. Methodology: Review of theoretical and empirical findings, and autoethnography taking a scientist-practitioner stance. Results: A comprehensive, practical, integrated, flexible, and evidence-based model for the prevention and treatment of depression, and other internalizing disorders. Utility: This model will be of interest to researchers, practitioners, students of psychology, and the wider public. Conclusion/Recommendations: The model can be used to promote preventative factors in youth development, develop protective factors in high-risk populations with vulnerability to depression, and treat individuals experiencing depression or other internalizing disorders.
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