ATYPICAL HEMOLYTIC UREMIC SYNDROME: A RARE CAUSE OF MALIGNANT HYPERTENSION AND ACUTE RENAL FAILURE IN ADULT

摘要

Introduction: Atypical hemolytic uremic syndrome (aHUS) is a form of complement-mediated thrombotic microangiopathy mainly characterized by excessive activation of alternative complement pathway activation. This occurs due to mutation in the complement regulatory proteins or by acquired neutralizing antibodies to these complement regulatory proteins. It is characterized by a triad of microangiopathic hemolytic anemia, thrombocytopenia and acute kidney injury. It usually has a poor prognosis in the absence of prompt recognition and treatment, with more than 50% of the patients progressing to end stage renal disease.