THE ROLE OF KIDNEY BIOPSY AND QUANTITATIVE COMPUTER MORPHOMETRY IN PREDICTING THE REVERSIBILITY OF DIALYSIS-DEPEND ACUTE KIDNEY INJURY DUE TO MYELOMA CAST NEPHROPATHY

摘要

Introduction: Myeloma cast nephropathy (MCN) is morphologically confirmed in 87–94% of patients with dialysis-dependent acute kidney injury (AKI) at multiple myeloma onset. However, kidney biopsy is necessary to detect paraprotein-related nephropathy. Recent studies have shown that kidney biopsy allows not only to establish the nature of damage, but also to determine severity and potential reversibility of pathological process. Clinically this can be helpful in choosing the optimal treatment program of MCN.