An in silico epitope-based peptide vaccine design against the 2019-nCoV

摘要

The 2019-nCoV is a novel SARS coronavirus which was first isolated from three individuals having pneumonia with connection to the Wuhan epidemic of the severe respiratory illness [1].The 2019-nCoV shares a dose relationship with the original SARS-CoV, and it is believed to exhibit a zoonotic property. Genomic analysis of the virus has shown that it clusters genetically with the Beta coronavirus genus, alongside two other strains derived from bat. It shares a 96% identity with other bat coronavirus samples (Bat Cov RaTG 13) at the whole genome level. Chinese researchers in February 2020 discovered the amino acid difference in specific parts of the human and pangolin virus genome sequences, however, whole-genome comparison between the pangolin coronavirus, and the 2019-nCoV found a maximum of 92% identical genetic materials, which has so far not been sufficient enough to confirm pangolins to be the viral intermediate host [2].