Controlling Silver Ion Release of Silver Nanoparticles with Hybrid Lipid Membranes with Long-Chain Hydrophobic Thiol Anchors Decreases in Vivo Toxicity

摘要

Silver nanoparticles (AgNPs) are widely used in various commercial and industrial applicationsbecause of their antimicrobial properties.The behavior and toxicity of AgNPs are likely controlled by physicochemical properties such as size, shape, and surface chemistry; however, studies of these properties are often confounded by Ag ion dissolution. Here a suite of spherical and triangular shaped AgNPs were prepared with increasing amounts of surface protection from their surface-coating comprising of citrate (Cit) only or a mixture.