Crystal Structure of Enoyl‐Acyl Carrier Protein Reductase (FabI) from Acinetobacter baumannii as a Target for Broad‐Spectrum Antibacterial Drug

Gyunbo Seol; Hyunjae Park; YehJin Ahn; LinWoo Kang

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Crystal Structure of Enoyl‐Acyl Carrier Protein Reductase (FabI) from Acinetobacter baumannii as a Target for Broad‐Spectrum Antibacterial Drug

机译：eNoyl-酰基载体蛋白还原酶（Fabi）的晶体结构来自肺杆菌的植物为广谱抗菌药物的靶标

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Crystal Structure of Enoyl‐Acyl Carrier Protein Reductase (FabI) proposes a putative inhibitor binding pocket.

机译：烯库 - 酰基载体蛋白质还原酶（Fabi）的晶体结构提出了一种推定的抑制剂结合口袋。

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《Bulletin of the Korean Chemical Society》 |2019年第10期|共4页
作者
Gyunbo Seol; Hyunjae Park; YehJin Ahn; LinWoo Kang;
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中图分类化学;
关键词
NADHdependent enoylacyl carrier protein reductase (FabI)Acinetobacter baumanniiType II fatty acid synthetic pathwayXray crystallographyAntibacterial drug target;

机译：Nadhdependent Enoylaceryl载体蛋白质还原酶（Fabi）肺杆菌Baumanniitype II脂肪酸合成途径XRAY晶体纤维药物靶标;

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1. Crystal Structure of Enoyl-Acyl Carrier Protein Reductase(FabI)from Acinetobacter baumannii as a Target for Broad-Spectrum Antibacterial Drug [J] . Gyunbo Seol, Hyunjae Park, Yeh-Jin Ahn Bulletin of the Korean Chemical Society . 2019,第10期

机译：eNoyl-酰基载体蛋白还原酶（Fabi）的晶体结构来自肺杆菌的植物为广谱抗菌药物的靶标
2. Acinetobacter baumannii Acinetobacter baumannii has a novel β‐ketoacyl‐acyl carrier protein synthase III (KAS III), which can feed long, host‐derived fatty acyl‐CoA molecules into de novo fatty acid synthesis. The crystal structure of KAS III reveals structural changes in the active site that allow accommodation of octanoyl‐CoA. For details, see the article by Lee et al. on pp. 567–577 of this issue. [J] . Molecular Microbiology . 2018,第5期

机译：AcineTobacterBaumannii AcineTobacter Baumannii具有一种新型β-酮酰基 - 酰基载体蛋白合成酶III（KAS III），其可以将长的宿主衍生的脂肪酰基-CoA分子提供给De Novo脂肪酸合成。 KAS III的晶体结构揭示了允许辛烷罗-CoA的容纳的活性位点的结构变化。有关详细信息，请参阅Lee等人的文章。在本问题的第567-577页。
3. Structures of Pseudomonas aeruginosa-ketoacyl-(acyl-carrier-protein) synthase II (FabF) and a C164Q mutant provide templates for antibacterial drug discovery and identify a buried potassium ion and a ligand-binding site that is an artefact of the crystal form [J] . Baum Bernhard, Lecker Laura S. M., Zoltner Martin, Acta crystallographica. Section F, Structural biology communications . 2015,第8期

机译：假单胞菌铜酮 - 酮烷基 - （酰胺蛋白）合成酶II（FABF）和C164Q突变体的结构提供了抗菌药物发现的模板，并鉴定掩埋钾离子和作为晶体形式的人工制品的配体结合位点
4. Malonyl-CoA: acyl carrier protein transacylase from Helicobacter pylori: Crystal structure and its interaction with acyl carrier protein [C] . LIANG ZHANG, WEIZHI LIU, JIANFENG XIAO, 第四届国际分子模拟与信息技术应用学术会议（The 4th International Conference of Molecular Simulations and Applied Informatics Technologies）论文集 . 2008

机译：丙二酰辅酶A：幽门螺杆菌的酰基载体蛋白转酰基酶：晶体结构及其与酰基载体蛋白的相互作用
5. The Structures of Biofilm-Controlling Proteins from Acinetobacter baumannii and Bacillus subtilis Reveal Details of DNA-binding Mechanisms and Illuminate Potential Therapeutic Targets. [D] . Draughn, George Logan. 2017

机译：鲍曼不动杆菌和枯草芽孢杆菌的生物膜控制蛋白的结构揭示了DNA结合机制的细节，并阐明了潜在的治疗靶标。
6. Structures of Pseudomonas aeruginosa β-ketoacyl-(acyl-carrier-protein) synthase II (FabF) and a C164Q mutant provide templates for antibacterial drug discovery and identify a buried potassium ion and a ligand-binding site that is an artefact of the crystal form [O] . Bernhard Baum, Laura S. M. Lecker, Martin Zoltner, 2015

机译：铜绿假单胞菌β-酮酰基-（酰基载体蛋白）合酶II（FabF）和C164Q突变体的结构为发现抗菌药物提供了模板并鉴定了掩埋的钾离子和作为晶体形式人工产物的配体结合位点
7. Acinetobacter baumannii has a novel β-ketoacyl-acyl carrier protein synthase III (KAS III), which can feed long, host-derived fatty acyl-CoA molecules into de novo fatty acid synthesis. The crystal structure of KAS III reveals structural changes in the ac [O] . 2018

机译：AcineTobacterBaumannii具有新型β-酮酰基 - 酰基载体蛋白合成酶III（KAS III），其可以将长的宿主衍生的脂肪酰基-CoA分子提供给De Novo脂肪酸合成。 KAS III的晶体结构揭示了AC的结构变化

Crystal Structure of Enoyl‐Acyl Carrier Protein Reductase (FabI) from Acinetobacter baumannii as a Target for Broad‐Spectrum Antibacterial Drug

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