Choline Hydroxide as a Versatile Medium for Catalyst‐Free O‐Functionalization of Phenols

摘要

A versatile synthetic protocol for benzyl phenyl ether preparation via O‐alkylation of phenolic oxygen with readily available benzyl derivatives was demonstrated. The newly designed procedure was carried out using an eco‐friendly medium, room‐temperature ionic liquid (choline hydroxide), under metal‐ and base‐catalyst‐free aerobic conditions. The reaction platform was also successfully applied to phenol protection strategy.