Choline Hydroxide as a Versatile Medium for Catalyst-Free O-Functionalization of Phenols

摘要

A versatile synthetic protocol for benzyl phenyl ether preparation via Oalkylation of phenolic oxygen with readily available benzyl derivatives was demonstrated. The newly designed procedure was carried out using an eco-friendly medium, room-temperature ionic liquid (choline hydroxide), under metal- and base-catalyst-free aerobic conditions. The reaction platform was also successfully applied to phenol protection strategy.