Coronavirus Disease (COVID-19) Outbreak and Adaptive Immune System of the Body A Review

摘要

In December 2019, a severe disease with an unknown aetiology has appeared in a Wuhan City, Hubei province, China.Immediately, it was identified as novel Coronavirus Disease (COVID-19) that has spread globally and also called Severe AcuteRespiratory Syndrome Coronavirus-2 (SARS-CoV-2), and was characterised in China. As we know the presence of viruses withnew genetic diversity in nature, it is unclear from where this virus has evolved and transmitted to humans at the first place. As theoutbreak of COVID-19 progresses, epidemiological data is essential to guide situational awareness, and intervention strategiesand also immune response in COVID-19. That’s why treatments dealing with the immune-pathology of SARS-CoV-2 infectionis a major issue for focus now-a-days, while a rapid and well-coordinated immune response represent the first line of defenceagainst the viral infection. Presently, limited data and information is available on the host innate and adaptive i mmune statusof SARS-CoV-2 infected patients. Here, authors described that how the immune system plays the first line of defence againstviral infection, and attempt to compile, accumulate and disseminate the immune response information on COVID-19 from theWorld Health Organisation (WHO), MEDLINE, Embase, Cochrane Library, Centers for Disease Control and Prevention COVID-19 Research Database and trials registries for the recognition in progress and finished studies, cohort, and from RandomisedControlled Trials (RCTs).