Synthesis of β-phthalimido-alcohols via regioselective ring opening of epoxide by using reusable basic magnetic nano particles and their biological investigation

摘要

In this work, tetra butyl ammonium hydroxide ([Bu _(4) N]OH) and magnetic nano particles (Fe _(3) O _(4) @SiO _(2) @(CH _(2) ) _(3) NH _(2) ) were introduced as efficient catalysts for the regioselective ring opening of epoxides including aromatic and aliphatic of epoxides to give the corresponding β-phthalimido-alcohols under mild conditions. A various range of β-phthalimido-alcohols as new compounds were prepared and fully characterized by IR, ~(1) H as well as ~(13) C NMR and mass spectra. Also the synthesized compounds were studied for antioxidant properties by DPPH free radical scavenging assay. The results indicated that studied β-phthalimido-alcohols derivatives have effective antioxidant functions (IC _(50) : 0.142–0.356 mg mL ~(?1) ) in compare with BHT (IC _(50) : 0.122 mg mL ~(?1) ) and ascorbic acid (IC _(50) : 0.146 mg mL ~(?1) ) as standards. This may be a new health-care food and drug supplement for special use in the future.