首页> 外文期刊>Nature Communications >Adipose group 1 innate lymphoid cells promote adipose tissue fibrosis and diabetes in obesity
【24h】

Adipose group 1 innate lymphoid cells promote adipose tissue fibrosis and diabetes in obesity

机译:脂肪组1先天淋巴细胞促进肥胖组织纤维化和糖尿病

获取原文
       

摘要

Pathogenic factors driving obesity to type 2 diabetes (T2D) are not fully understood. Group 1 innate lymphoid cells (ILC1s) are effectors of innate immunity and enriched in inflamed tissues. Here we show that the number of adipose ILC1s increases in obese T2D patients and correlates with glycemic parameters and with the number of ILC1s in the blood; circulating ILC1 numbers decrease as a result of metabolic improvements after bariatric surgery. In?vitro co-culture experiments show that human adipose ILC1s promote adipose fibrogenesis and CD11csup+/sup macrophage activation. Reconstruction of the adipose ILC1 population in Prkdcsup-/-/supIL2rgsup-/-/sup mice by adoptive transfer drives adipose fibrogenesis through activation of TGFβ1 signaling; however, transfer of Ifngsup-/-/sup ILC1s has no effect on adipose fibrogenesis. Furthermore, inhibiting adipose accumulation of ILC1s using IL-12 neutralizing antibodies attenuates adipose tissue fibrosis and improves glycemic tolerance. Our data present insights into the mechanisms of local immune disturbances in obesity-related T2D.
机译:促进肥胖的致病因素尚未得到完全理解2型糖尿病(T2D)。第1组先天淋巴细胞(ILC1s)是先天免疫的效果,并富含发炎组织。在这里,我们表明肥胖ILC1s的数量增加肥胖的T2D患者,并与血糖参数相关,血液中的ILC1s数量相关;由于肥胖手术后代谢改善,循环ILC1数减少。体外共培养实验表明,人脂肪ILC1S促进脂肪纤维发生和CD11c + / sup>巨噬细胞活化。采用PRKDC - / - / - / sup> IL2RG - / - / - / - / - / - / - / - 小鼠通过激活TGFβ1信号传导,重建PRKDC - / - / - IL2RG - / - / - / - / - / - / - / - / - / - / - / - / - / - / - / - / - / - / - / - / - / - / - / - / - / - / - / - / - / - / - / - / - 小鼠;然而,IFNG - / - / sup> ILC1s对脂肪纤维发生没有影响。此外,使用IL-12中和抗体抑制ILC1s的脂肪累积衰减脂肪组织纤维化并提高血糖耐受性。我们的数据显示了肥胖相关T2D中局部免疫紊乱机制的见解。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号