Model-based Modified OGTT Insulin Sensitivity Test Design

摘要

Type 2 diabetes mellitus requires early, accurate, and efficient monitoring for best treatment. Current common diagnosis tools either test late-appearing symptoms, are low resolution, or are expensive in cost and time. A system of physiological models for the oral ingestion of glucose, subcutaneous injection of insulin, and glycaemic control, are used to generate a quantitative test for insulin sensitivity. The proposed test uses35gof oral glucose, 2.0 units of rapid-acting insulin, and both intra-venous and finger-prick blood samples for insulin, C-peptides, and blood glucose levels frequently over a 2-hour period. The test is developedin silicoto enable early and repetitive monitoring of the pathogenesis of type 2 diabetes. In conjunction with emerging technologies in insulin sensing and needle-free delivery and monitoring devices, there is a pathway with this test to provide more effective, efficient early diagnosis of diabetes risk.